Pseudomembranous colitis by Clostridium difficile infection: a case report in pediatric patient

  • Johanna Villamarín Technical University of Ambato. Faculty of Health Sciences. Career of Medicine. Ecuador
  • Ruth Mejía Technical University of Ambato. Faculty of Health Sciences. Career of Medicine. Ecuador
  • Patricia Paredes Hospital IESS Ambato. Servicio de Pediatría. Ecuador
  • Sandra Villacís Technical University of Ambato. Faculty of Health Sciences. Career of Medicine. Ecuador
  • Yenddy Carrero Technical University of Ambato. Faculty of Health Sciences. Career of Medicine. Ecuador
Keywords: diarrhea, pseudomembranous colitis, Clostridium difficile

Abstract

Clostridium difficile is a bacillus Gram positive and spore form, anaerobic strictly, resistant to adverse conditions and transmitted by oral - fecal route, it was described by the first time in 1930, nevertheless it’s has been associated to disease in human beings in the decade of the seventies it identified as causal agent of pseudomembranous colitis. Its infection has related to diverse clinical manifestations such as diarrhea without complications, which lead to sepsis and inclusive the death. In the following clinical case we have a male infant 1 year old and 18 months patient, with precedents of hyperthermia and liquid depositions, after several days of antibiotics treatment, the symptoms increased with elimination of membranous rest in the faeces; reason why he is transferred to a hospital, in which the Clostridium difficile toxins test is realized, yielding positive results, therefore the diagnosis of pseudomembranous colitis is established metronidazole and vancomycin is given for 7 days having a favorable development. The use of antibiotics is a predisposing factor of pseudomembranous colitis for the affectation of the intestinal microbiota, in addition hospital stays and intrinsic factors. The literature describes a limited number of studies about this infection in pediatric patients, hence the importance of the case report

References

Orellana A, Salazar E.. Colitis Pseudomembranosa asociada al uso de antibióticos.ActaOdont,2009;47(2).Disponibleen:https://www.actaodontologica.com/ediciones/2009/2/art-25/ (acceso 25.06.17)

Meyer-S L, Espinoza-A R, Quera-P R. Infección por Clostridium difficile: epidemiología, diagnóstico y estrategias terapéuticas. Rev. Med. Clin.CONDES, 2014; 25(3): 473-484.

Voth DE, Ballard JD. Action and role in disease Clostridium difficile toxins: Mechanism of action and role in disease. ClinMicrobiol. Rev, 2005; 18 (2):247-63.

Poutanen SM, Simor AE. Clostridium difficile-associated diarrhea in adults. CMAJ, 2004; 171(1): 51-58.

Tenover FC, Baron EJ, Peterson LR, Persing DH. Laboratory diagnosis of

Clostridium difficile infection. Can molecular amplification methods move usout of uncertainty? J MolDiagn, 2011; 13: 573-582.

Pérez C. Probióticos en la diarrea aguda y asociada al uso de antibióticos en Pediatría. NutriciónHospitalaria,2015; 31(Supl. 1):64-67.

Alonso-Sanz MGAMJ. New methodological advances: Algorithm proposal for management of Clostridium difficile infection. Revista Española de Quimioterapia, 2015; 28(3):157-159.

Asensio A, Mongue D. Epidemiología de la infección por Clostridium difficile en España. Revisión. Enferm Infecc Microbiol Clin, 2012; 30:333-7.

Blanco-Pérez A, Ruiz O, Otero W, Gómez M. Infección por Clostridium difficile en ancianos. Artículo de Revisión. Rev Col Gastroenterol, 2013; 28 (1): 53-63.

Debast SB, Bauer MP, Kuiiper EJ. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clinical microbiology and infection.Clin Microbiol Infect, 2014; Suppl 2:1-26. doi: 10.1111/1469-0691.12418

Published
2017-12-04
How to Cite
1.
Villamarín J, Mejía R, Paredes P, Villacís S, Carrero Y. Pseudomembranous colitis by Clostridium difficile infection: a case report in pediatric patient. Kasmera [Internet]. 2017Dec.4 [cited 2024May22];45(2):100-6. Available from: https://produccioncientificaluz.org/index.php/kasmera/article/view/23060
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Original Articles